Articles

Risk factors for postneonatal, infant, child and under-5 mortality in Nigeria: a pooled cross-sectional analysis

The study aims to identify common factors associated with post-neonatal, infant, child and under-5 mortality in Nigeria. This study found that no formal education, poor households and living in rural areas increased the risk of postneonatal, infant, child and under-5 mortality among Nigerian children. Community-based interventions for reducing under-5 deaths are needed and should target children born to mothers of low socioeconomic status.      

Supporting adolescent girls to stay in school, reduce child marriage and reduce entry into sex work as HIV risk prevention in north Karnataka, India: protocol for a cluster randomised controlled trial

Low caste adolescent girls living in rural northern Karnataka are at increased risk of school drop-out, child marriage, and entry into sex-work, which enhances their vulnerability to HIV, early pregnancy and adverse maternal and child health outcomes. This protocol describes the evaluation of Samata, a comprehensive, multi-level intervention designed to address these structural drivers of HIV risk and vulnerability.      

Associations between parental BMI, socioeconomic factors, family structure and overweight in Finnish children: a path model approach

The aim of this study was to assess the less studied interrelationships and pathways between parental BMI, socioeconomic factors, family structure and childhood overweight. The observed pathways between parental BMI and education and childhood overweight emphasize a need for evidence-based health promotion interventions tailored for families identified with parental overweight and low level of education.      

INTERGROWTH-21st Newborn Birth Length Standards and Z Scores

Global standards and z scores for length at birth, with information related to their use. Online calculators will be available shortly.

INTERGROWTH-21st Newborn Head Circumference Standards and Z Scores

Global standards and z scores for head circumference at birth, with information related to their use. Online calculators will be available shortly. 

INTERGROWTH-21st Newborn Birth Weight Standards and Z Scores

Global standards and z scores for birth weight at birth, with information related to their use. Online calculators will be available shortly.  

Association between gender inequality index and child mortality rates: a cross-national study of 138 countries

Gender inequality weakens maternal health and harms children through many direct and indirect pathways. The global impact of Gender Inequality Index (GII) on the child mortality rates remains uncertain. The study authors have documented statistically significant positive associations between GII and child mortality rates. The authors suggest that initiatives to curtail child mortality rates should extend beyond medical interventions and should prioritize women’s rights and autonomy.      

Maternal smoking and the risk of still birth: systematic review and meta-analysis

Smoking in pregnancy is known to be associated with a range of adverse pregnancy outcomes, yet there is a high prevalence of smoking among pregnant women in many countries, and it remains a major public health concern. The authors have conducted a systematic review and meta-analysis to provide contemporary estimates of the association between maternal smoking in pregnancy and the risk of stillbirth. The review findings confirm a dose-response effect of maternal smoking in pregnancy on risk of stillbirth. To minimise the risk of stillbirth, reducing current smoking prevalence in pregnancy should continue to be a key public health high priority.      

Demonstrating the Efficacy of the FoneAstra Pasteurization Monitor for Human Milk Pasteurization in Resource-Limited Settings

Rubella

Rubella remains an important pathogen worldwide, with roughly 100 000 cases of congenital rubella syndrome estimated to occur every year. This seminar present results regarding rubella control, elimination, and eradication policies, and a brief review of new laboratory diagnostics.      

Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5–9 years in Greenland, Ukraine and Poland

Study findings suggest that In utero exposure to CB-153 and p,p′-DDE was not associated with parentally retrospectively assessed developmental milestones in infancy or parentally assessed motor skills at young school age. The use of a more sensitive outcome measure may be warranted if subtle effects should be identified.      

Home treatments: changes following research

We repeated, 10 years apart, the retrospective treatment-outcome study on 400 children with presumed malaria in the same area (Argemone mexicana decoction).

Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement

The authors in this paper describe the development of a reporting guideline, the Preferred Reporting Items for Systematic reviews and Meta-Analyses for Protocols 2015 (PRISMA-P 2015). PRISMA-P consists of a 17-item checklist intended to facilitate the preparation and reporting of a robust protocol for the systematic review. Funders and those commissioning reviews might consider mandating the use of the checklist to facilitate the submission of relevant protocol information in funding applications. Similarly, peer reviewers and editors can use the guidance to gauge the completeness and transparency of a systematic review protocol submitted for publication in a journal or other medium.      

Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis

Trend data for causes of child death are crucial to inform priorities for improving child survival by and beyond 2015. We report child mortality by cause estimates in 2000–13, and cause-specific mortality scenarios to 2030 and 2035. The authors in this study estimated the distributions of causes of child mortality separately for neonates and children aged 1–59 months      

Effects of bed nets and anti-malaria drugs use on childhood mortality in Kenya’s malaria endemic and epidemic areas

This study seeks to establish differentials in childhood mortality rates by these interventions in three malaria prone areas defined as highland epidemic, coast endemic and lake endemic. It also seeks to determine the effects of these interventions on childhood mortality. This study underscore the need for increasing uptake of malaria interventions and complementing them with longer breastfeeding duration and improved toilet facility in efforts towards reducing infant and child mortality rates in Kenya?s malaria prone areas. There is also need to improve quality of individual household data for malaria module in future KDHS undertakings.      

WHO Global Nutrition Targets 2025: low birth weight policy brief

This WHO policy brief is part of a series on six global nutrition targets for 2025. This brief covers the third target: a 30% reduction in low birth weight. The purpose of the brief is to increase attention to, investment in, and action for a set of cost effective interventions and policies that can help WHO Member States and their partners in reducing rates of low birth weight. INTERGROWTH-21st Chief Investigators Stephen Kennedy and Jose Villar provided expert review of these strategies, contributing the unique perspective that data from the Project, and the resulting growth standards and tools as part of overall strategies for reducing rates of low birth weight in settings across the globe. The  full policy brief series can be found here: http://www.who.int/nutrition/publications/globaltargets2025_policybrief_overview/en/

Reviews: Rapid! Rapid! Rapid! ...and systematic

The methodology of systematic reviews—although laid out three or more decades ago—is continuously and rapidly updated by scientists specializing in research synthesis. Now, Systematic Reviews is publishing a series of articles including methods and examples of accelerating approaches to conducting literature reviews.      

Association between Respiratory Syncytial Virus Activity and Pneumococcal Disease in Infants: A Time Series Analysis of US Hospitalization Data

The importance of bacterial infections following respiratory syncytial virus (RSV) remains unclear. The authors in this study evaluated whether variations in RSV epidemic timing and magnitude are associated with variations in pneumococcal disease epidemics and whether changes in pneumococcal disease following the introduction of seven-valent pneumococcal conjugate vaccine (PCV7) were associated with changes in the rate of hospitalizations coded as RSV. These analyses provide evidence for an interaction between RSV and pneumococcal pneumonia. Future work should evaluate whether treatment for secondary bacterial infections could be considered for pneumonia cases even if a child tests positive for RSV.        

The Distribution of Clinical Phenotypes of Preterm Birth Syndrome: Implications for Prevention

Preterm birth has been difficult to study and prevent because of its complex syndromic nature. The INTERGROWTH-21st Project presents a new approach to this problem. This paper explains the results of the first application of a prototype classification system for preterm birth based on twelve phenotypes, using data from the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project. http://archpedi.jamanetwork.com/article.aspx?articleid=2050591

The association between breastfeeding and childhood obesity: a meta-analysis

The increase in childhood obesity is a serious public health concern. Several studies have indicated that breastfed children have a lower risk of childhood obesity than those who were not breastfed, while other studies have provided conflicting evidence. The objective of this meta-analysis was to investigate the association between breastfeeding and the risk of childhood obesity. Results of our meta-analysis suggest that breastfeeding is a significant protective factor against obesity in children.