Inadequate illness recognition and access to antibiotics contribute to high case fatality from infections in young infants (<2 months) in low- and middle-income countries (LMICs). This study aimed to address three questions regarding access to treatment for young infant infections in LMICs: (1) Can frontline health workers accurately diagnose possible bacterial infection (pBI)?; (2) How available and affordable are antibiotics?; (3) How often are antibiotics procured without a prescription?
Findings suggest that trained frontline health workers may screen for pBI in young infants with relatively high sensitivity and lower specificity. Availability of first-line injectable antibiotics appears low in many health facilities in Africa and Asia. Improved data and advocacy are needed to increase the availability and appropriate utilization of antibiotics for young infant infections in LMICs.
Seale AC, Blencoe H, Zaidi A, Ganatra H, Syed S, et al. (2013) Neonatal severe bacterial infection impairment estimates in South Asia, sub-Saharan Africa, and Latin America for 2010. Pediatr Res 74 Suppl 1: 73–85. doi: 10.1038/pr.2013.207
Thaver D, Zaidi AK (2009) Burden of neonatal infections in developing countries: a review of evidence from community-based studies. Pediatr Infect Dis J 28: S3–9. doi: 10.1097/inf.0b013e3181958755
Liu L, Johnson HL, Cousens S, Perin J, Scott S, et al. (2012) Child Health Epidemiology Reference Group of WHO and UNICEF (2012) Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet 379: 2151–2161. doi: 10.1016/s0140-6736(12)60560-1
Lawn JE, Cousens S, Darmstadt GL, Paul V, Martines J (2004) Why are 4 million newborn babies dying every year? Lancet 364: 2020. doi: 10.1016/s0140-6736(04)17511-9
Ganatra HA, Stoll BJ, Zaidi AK (2010) International perspective on early-onset neonatal sepsis. Clin Perinatol 37: 501–523. doi: 10.1016/j.clp.2010.02.004
Stoll BJ (1997) The global impact of neonatal infection. Clin Perinatol 24: 1–21.