The authors aimed to investigate whether antibiotic prophylaxis prevented maternal infection after operative vaginal birth. In a blinded, randomised controlled trial done at 27 UK obstetric units, women (aged ≥16 years) were allocated to receive a single dose of intravenous amoxicillin and clavulanic acid or placebo (saline) following operative vaginal birth at 36 weeks gestation or later. The primary outcome was confirmed or suspected maternal infection within 6 weeks of delivery defined by a new prescription of antibiotics for specific indications, confirmed systemic infection on culture, or endometritis. This trial shows benefit of a single dose of prophylactic antibiotic after operative vaginal birth and guidance from WHO and other national organisations should be changed to reflect this.
Global Burden of Disease Causes of Death Collaborators. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017; 390: 1151-1210
Bonet M Souza JP Abalos E et al. The global maternal sepsis study and awareness campaign (GLOSS): study protocol.
Reprod Health. 2018; 15: 16
Smaill FM Grivell RM. Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean section.
Cochrane Database Syst Rev. 2014; 10 (CD007482.)