The objective of the study was to assess the relationship between allostatic load, a measure of cumulative chronic stress in early pregnancy and cardiovascular disease risk, 2-7 years postpartum, and pathways contributing to racial disparities in cardiovascular disease risk. Findings suggest that high allostatic load during pregnancy is associated with cardiovascular disease risk. The relationships between stress, subsequent cardiovascular risk and race warrant further study.

https://obgyn.onlinelibrary.wiley.com/doi/10.1111/1471-0528.17486

References

  1. Lueth AJ, Allshouse AA, Blue NM, Grobman WA, Levine LD, Simhan HN, Kim JK, Johnson J, Wilson FA, Murtaugh M, Silver RM; National Institutes of Health (NIH), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b), and National Heart, Lung, and Blood Institute (NHLBI) nuMoM2b Heart Health Study (nuMoM2b-HHS). Allostatic Load and Adverse Pregnancy Outcomes. Obstet Gynecol. 2022 Dec 1;140(6):974-982. doi: 10.1097/AOG.0000000000004971. Epub 2022 Nov 2. PMID: 36357956

  2. Barrett ES, Vitek W, Mbowe O, Thurston SW, Legro RS, Alvero R, Baker V, Bates GW, Casson P, Coutifaris C, Eisenberg E, Hansen K, Krawetz S, Robinson R, Rosen M, Usadi R, Zhang H, Santoro N, Diamond M. Allostatic load, a measure of chronic physiological stress, is associated with pregnancy outcomes, but not fertility, among women with unexplained infertility. Hum Reprod. 2018 Sep 1;33(9):1757-1766. doi: 10.1093/humrep/dey261.

  3. Parker HW, Abreu AM, Sullivan MC, Vadiveloo MK. Allostatic Load and Mortality: A Systematic Review and Meta-Analysis. Am J Prev Med. 2022 Jul;63(1):131-140. doi: 10.1016/j.amepre.2022.02.003. Epub 2022 Apr 4.

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