This study aimed to study the causal association between analgesic opioids in pregnancy and placental abruption, pre-eclampsia, preterm birth, and fetal growth restriction (FGR). In this population-based cohort study, we observed modestly increased risks of preterm birth and placental abruption after analgesic opioid use in pregnancy, driven by codeine and oxycodone-the two most frequently used opioids.

https://pubmed.ncbi.nlm.nih.gov/40795075/

References

  1. Brett JGM, Bateman BT, Chan AYL, Cheng MCY, Zoega H.  Global trends in analgesic opioid use in pregnancy: a retrospective cohort study. Anaesthesiology  2024;142:110.

  2. Zur RL, McLaughlin K, Aalto L  et al.  Phenotypes of maternal vascular malperfusion placental pathology and adverse pregnancy outcomes: a retrospective cohort study. BJOG Int J Obstetr Gynaecol  2024;131:1515–23. 

  3. Shanmugalingam R, Barrett HL, Beech A  et al.  A summary of the 2023 Society of Obstetric Medicine of Australia and New Zealand (SOMANZ) hypertension in pregnancy guideline. Med J Aust  2024;220:582–91

Categories

Maternal & Infant Health  Maternal Health  Maternal/Fetal health during pregnancy  

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