This study examined the risks of adverse perinatal outcomes associated with antidepressant use during pregnancy. Both depression and antidepressant use were independently associated with the risk of adverse perinatal outcomes; however, the risk associated with antidepressants was higher over and above the risk associated with depression. This may reflect the biological effects of antidepressants, greater severity of depression in those treated, or both.


  1. Lynch MM, Squiers LB, Kosa KM, et al. Making decisions about medication use during pregnancy: Implications for communication strategies. Matern Child Health J. 2018;22(1):92‐100.

  2. Cantarutti A, Merlino L, Giaquinto C, Corrao G. Use of antidepressant medication in pregnancy and adverse neonatal outcomes: A population‐based investigation. Pharmacoepidemiol Drug Saf. 2017;26(9):1100‐8

  3. Norby U, Forsberg L, Sjors G, Wide K, Winbladh B, Kallen K. Neonatal morbidity after maternal use of antidepressant drugs during pregnancy. Pediatrics. 2016;138(5):e20160181.


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