This study examined the associations of COVID-19 vaccination and SARS-CoV-2 infection with fertility among couples trying to conceive spontaneously using data from an internet-based preconception cohort study. Findings indicate that male SARS-CoV-2 infection may be associated with a short-term decline in fertility and that COVID-19 vaccination does not impair fertility in either partner.


  1. Crowe HM, Wesselink AK, Wise LA, Wang TR, Horsburgh CR, Mikkelsen EM, Hatch EE. Antibiotics and fecundability among female pregnancy planners: a prospective cohort study. Hum Reprod. 2021 Sep 18;36(10):2761-2768. doi: 10.1093/humrep/deab173.

  2. Stanford JB, Willis SK, Hatch EE, Rothman KJ, Wise LA. Fecundability in relation to use of mobile computing apps to track the menstrual cycle. Hum Reprod. 2020 Oct 1;35(10):2245-2252. doi: 10.1093/humrep/deaa176.

  3. Wesselink AK, Rothman KJ, Hatch EE, Mikkelsen EM, Sørensen HT, Wise LA. Age and fecundability in a North American preconception cohort study. Am J Obstet Gynecol. 2017 Dec;217(6):667.e1-667.e8. doi: 10.1016/j.ajog.2017.09.002. Epub 2017 Sep 14


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