The study objectives were to determine perinatal outcomes after an OUD diagnosis and associations between opioid agonist treatment and birth outcomes. Findings suggest that perinatal OUD in British Columbia tripled in incidence over a 20-year period. Sustained opioid agonist treatment during pregnancy reduced the risk of adverse birth outcomes, highlighting the need for expanded services, including opioid agonist treatment to support mothers and infants.


  1. Nielsen T, Bernson D, Terplan M, Wakeman SE, Yule AM, Mehta PK, Bharel M, Diop H, Taveras EM, Wilens TE, Schiff DM. Maternal and infant characteristics associated with maternal opioid overdose in the year following delivery. Addiction. 2020 Feb;115(2):291-301. doi: 10.1111/add.14825. Epub 2019 Nov 13.

  2. Paterno MT, Jablonski L, Klepacki A, Friedmann PD. Evaluation of a Nurse-Led Program for Rural Pregnant Women With Opioid Use Disorder to Improve Maternal-Neonatal Outcomes. J Obstet Gynecol Neonatal Nurs. 2019 Sep;48(5):495-506. doi: 10.1016/j.jogn.2019.07.002. Epub 2019 Jul 30.

  3. Brogly SB, Turner S, Lajkosz K, Davies G, Newman A, Johnson A, Dow K. Infants Born to Opioid-Dependent Women in Ontario, 2002-2014. J Obstet Gynaecol Can. 2017 Mar;39(3):157-165. doi: 10.1016/j.jogc.2016.11.009.


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