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HIV-exposed but uninfected (HEU) infants are at an increased risk of many infectious diseases that can contribute to the high mortality seen among HEU children. Maternal immunisation could be a promising strategy to reduce infections in HEU infants. However, very little research has explored the effect of HIV on the immunogenicity and effectiveness of vaccines given during pregnancy. The authors reviewed the available evidence on maternal immunisation among women living with HIV (WLWH) for all vaccines recommended, considered, or being investigated for routine or risk-based use during pregnancy. Of the 11 vaccines included, only three have been investigated in WLWH. Available evidence suggests that maternal HIV infection limits the immunogenicity of several vaccines, leaving HEU infants more susceptible to infection during their first few months of life. Whether maternal immunisation reduces the infectious morbidity and mortality associated with infectious diseases in HEU children remains unknown.


  1. UNAIDS. UNAIDS Data 2017. 2017. Joint United Nations Programme on HIV/AIDS.

  2. Arikawa S Rollins N Newell ML Becquet R. Mortality risk and associated factors in HIV-exposed, uninfected children.
    Trop Med Int Health. 2016; 21: 720-734

  3. Jones CE Naidoo S De Beer C Esser M Kampmann B Hesseling AC
    Maternal HIV infection and antibody responses against vaccine-preventable diseases in uninfected infants.
    JAMA. 2011; 305: 576-584