The primary aim of this trial was to determine whether implementation of the CRADLE Vital Sign Alert and an education package into community and facility maternity care in low-resource settings could reduce a composite of all-cause maternal mortality or major morbidity (eclampsia and hysterectomy) across Africa, India, and HaitiThere was an absolute 8% reduction in primary outcome during the trial, with no change in resources or staffing, but this reduction could not be directly attributed to the intervention due to variability. The authors encountered unanticipated methodological challenges with this trial design, which can provide valuable learning for future research and inform the trial design of future international stepped-wedge trials.

https://www.ncbi.nlm.nih.gov/pubmed/30784635

References

  1. WHO/UNICEF/UNFPA/The World Bank and the United Nations Population Division. Trends in maternal mortality: 1990 to 2015. Estimates by WHO, UNICEF, UNFPA, The World Bank and the United Nations Population Division. World Health Organization, Geneva; 2015

  2. Say L Chou D Gemmill A et al. Global causes of maternal death: a WHO systematic analysis. Lancet Glob Health. 2014; 2: e323-e333

  3. Campbell OMR Graham WJ. Strategies for reducing maternal mortality: getting on with what works. Lancet. 2006; 368: 1284-1299

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