The positive association between caesarean section (CS) and autism spectrum disorder (ASD) may be attributed to preterm delivery. However, due to lack of statistical power, no previous study thoroughly examined this association across gestational age. The authors compared emergency versus planned CS to investigate their potential difference in the risk of ASD using population-based registries of four Nordic countries and Western Australia. Across the five countries, emergency or planned CS is consistently associated with a modest increased risk of ASD from gestational weeks 36 to 42 when compared with vaginal delivery.
References
Glasson EJ, Bower C, Petterson B, de Klerk N, Chaney G, Hallmayer JF. Perinatal factors and the development of autism: a population study. Archives of general Psychiatry. 2004 Jun 1;61(6):618-27.
Maimburg RD, Væth M. Perinatal risk factors and infantile autism. Acta Psychiatrica Scandinavica. 2006 Oct 1;114(4):257-64.
Larsson HJ, Eaton WW, Madsen KM, Vestergaard M, Olesen AV, Agerbo E, Schendel D, Thorsen P, Mortensen PB. Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status. American journal of epidemiology. 2005 May 15;161(10):916-25.
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