The objective of this study was to investigate the association between maternal smoking during pregnancy and offspring brain development in preadolescence as well as the mediating pathways. The findings of this cohort study suggest that continued maternal tobacco use during pregnancy was associated with lower brain volumes and suboptimal cortical traits of offspring in preadolescence, which seemed to be independent of shared family factors. Tobacco cessation before pregnancy, or as soon as pregnancy is known, should be recommended to women for optimal brain development of their offspring.


  1. Quelhas  D, Kompala  C, Wittenbrink  B,  et al.  The association between active tobacco use during pregnancy and growth outcomes of children under five years of age: a systematic review and meta-analysis.   BMC Public Health. 2018;18(1):1372.

  2. Quinn  PD, Rickert  ME, Weibull  CE,  et al.  Association between maternal smoking during pregnancy and severe mental illness in offspring.   JAMA Psychiatry. 2017;74(6):589-596

  3. Huang  L, Wang  Y, Zhang  L,  et al.  Maternal smoking and attention-deficit/hyperactivity disorder in offspring: a meta-analysis.   Pediatrics. 2018;141(1):e20172465. 


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