The primary objective of this study was to identify clinical risk factors associated with EOS by comparing neonates diagnosed with EOS to matched controls without early-onset sepsis (EOS). Conditional logistic regression was used for statistical analysis, adjusting for relevant maternal and neonatal covariates. This study provides the most comprehensive analysis to date of EOS risk in term neonates using a nationwide dataset. Findings indicate that cesarean delivery, maternal antibiotic use, specific maternal infections, maternal diabetes mellitus, premature rupture of membranes, and lower birth weight are associated with an increased risk of EOS. Further research is warranted to explore the potential causal relationships underlying these associations.
https://pubmed.ncbi.nlm.nih.gov/40859217/
References
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Lee HY, Hsu YL, Lee WY, Huang KH, Tsai ML, Chen CL, Chang YC, Lin HC. Maternal infections, antibiotics, steroid use, and diabetes mellitus increase risk of Early-Onset sepsis in preterm neonates: A nationwide Population-Based study. Pathogens (Basel Switzerland). 2025;14(1):89.
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