The objective of this study was to evaluate peripartum outcomes following COVID-19 vaccination during pregnancy. In this population-based cohort study in Ontario, Canada, COVID-19 vaccination during pregnancy, compared with vaccination after pregnancy and with no vaccination, was not significantly associated with increased risk of adverse peripartum outcomes. Study interpretation should consider that the vaccinations received during pregnancy were primarily mRNA vaccines administered in the second and third trimester.


  1. Allotey  J, Stallings  E, Bonet  M,  et al; for PregCOV-19 Living Systematic Review Consortium.  Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis.   BMJ. 2020;370:m3320.

  2. Karasek  D, Baer  RJ, McLemore  MR,  et al.  The association of COVID-19 infection in pregnancy with preterm birth: a retrospective cohort study in California.   Lancet Reg Health Am. 2021;2:100027.

  3. Villar  J, Ariff  S, Gunier  RB,  et al.  Maternal and neonatal morbidity and mortality among pregnant women with and without COVID-19 infection: the INTERCOVID multinational cohort study.   JAMA Pediatr. 2021;175(8):817-826. 


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